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ORIGINAL ARTICLE
Year : 2013  |  Volume : 27  |  Issue : 3  |  Page : 175-181

Clinical effects of intrathecal midazolam versus intrathecal magnesium sulfate as adjunctsto hyperbaric bupivacaine: A comparative study


Department of Anesthesiology, Axon Anesthesia Associates, Care Hospitals, Banjara Hills, Hyderabad, Andhra Pradesh, India

Correspondence Address:
Abhijit S Nair
Department of Anesthesiology, Axon Anesthesia Associates, Care Hospitals, Road Number 1, Banjara Hills, Hyderabad - 500 034, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-5333.124604

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Adjuvants are added to intrathecal local anesthetics to improve quality and duration of subarachnoid block. The present study was designed to compare the analgesic efficacy and quality of anesthesia produced by midazolam (1 mg) versus magnesium sulfate (50 mg) when given as adjuncts to hyperbaric bupivacaine intrathecally. In our study, we compared 1 mg midazolam and 50 mg magnesium sulfate as an additive to bupivacaine intrathecally. Materials and Methods: We conducted our study on 124 patients with(ASA) I and II physical status undergoing elective lower abdominal and orthopedic surgeries after approval from Institutional Ethics Committee. There were two groups; group MZ which received 3 ml of 0.5% heavy bupivacaine with 1 mg of preservative free midazolam and group MG which received 3 ml of 0.5% heavy bupivacaine with 50 mg magnesium sulfate intrathecally. The onset and duration of sensory block, onset and duration of motor block, and duration of analgesia were recorded. Results: The onset and duration of sensory block was longer in MG group as compared to the MZ group. The onset and duration of motor block was longer in MG group as compared to MZ group. Also, the total duration of analgesia was more in MG group as compared to MZ group. Conclusion: We concluded that 50 mg of intrathecal magnesium sulfate prolonged the duration of sensory and motor block and also the duration of postoperative analgesia with low pain scores as compared to midazolam group. However, it delayed the onset of sensory andmotor block. On the other hand 1 mg of intrathecal midazolam produced an early onset of sensory and motor block but the duration of analgesia was less as compared to the magnesium group.


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