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Year : 2014  |  Volume : 28  |  Issue : 1  |  Page : 5-12

Pain and inflammation: Management by conventional and herbal therapy

1 Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Plateau State, Nigeria
2 Department of Biochemistry, Covanent University, Ota, Ogun State, Nigeria

Correspondence Address:
David Arome
Department of Science Laboratory Technology, (Physiology and Pharmacology Tech), University of Jos - 23473
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-5333.128879

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The sensation of pain is an indication that something is wrong somewhere in the body. Pain and inflammation may be linked by cyclooxygenase (COX) enzymes most especially COX 2 , which help in the synthesis of prostaglandins (PGs) precisely PGE2 and PGF2a, found in high concentration at the inflammatory site. The released PGs either stimulate pain receptor or sensitized pain receptors to the action of other pain producing substances such as histamine, 5-hydroxytryptamine (5HT), bradykinin which initiate and cause the nerve cells to send electrical pain impulse to the brain. In the present review, an attempt is made to unveil the treatment approach adopted in the management of pain and inflammation as well as animal models used in evaluating herbal plants with analgesic and anti-inflammatory properties. The choice of the use of herbal medicine have been encouraged due to it availability, affordability, accessibility, and little or no side effect associated with it. However, the question remains can herbal therapy serves as an alternative to available conventional drugs. Different treatment options in the management of pain and inflammation have been highlighted.

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