Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online:1782
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2017  |  Volume : 31  |  Issue : 2  |  Page : 133-137

Role of oral gabapentin as preemptive adjuvant with spinal anesthesia for postoperative pain in patients undergoing surgeries under spinal anesthesia


1 Department of Anaesthesia and Critical Care, Mahatma Gandhi Mission Institute of Health Sciences, Mumbai, Maharashtra, India
2 Department of Anaesthesia and Critical Care, Institute of Naval Medicine, INHS Asvini, Maharashtra, India

Correspondence Address:
Deepak Dwivedi
Department of Anaesthesia and Critical Care, Institute of Naval Medicine, INHS Asvini, Colaba, Mumbai - 400 005, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpn.ijpn_36_17

Rights and Permissions

Background and Aims: The study was undertaken to evaluate postoperative benefit in patients administered tablet gabapentin as premedication with the primary outcome determining the effect on duration of analgesia with total analgesic requirement and measurement of postoperative sedation scores as our secondary outcomes. Methods: The study was a prospective randomized observational study in sixty patients undergoing surgeries in spinal anesthesia (SA). Patients were randomly assigned into two groups. Group A (n = 30) patients received tablet gabapentin (600 mg) while Group B (n = 30) received a placebo (Vitamin B complex) orally 2 h before surgery. Postoperative pain was managed with intravenous tramadol 2 mg/kg. Postoperative monitoring and assessment included pain assessment every 2 h with Numeric Rating Scale (0–10) for 12 h and then at 24 h. Results: On comparison of intergroup data, the duration of analgesia was prolonged in Group A (288.79 ± 38.81 min) as compared to Group B (218.67 ± 37.62 min) with P (0.0001). Total opioid requirement was higher in placebo group as compared to the Group A (P = 0.025). Statistical difference in mean (standard deviation) pain score at 24 h was statistically significant (P = 0.0002). Sedation scores were significantly higher in Group A at 2 and 4 h post-SA. Conclusion: Single dose of gabapentin administered 2 h before surgery provides better pain control as compared to placebo. It prolongs the duration of analgesia, reduces the total analgesic requirement during the postoperative period.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1066    
    Printed16    
    Emailed0    
    PDF Downloaded147    
    Comments [Add]    

Recommend this journal