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Year : 2017  |  Volume : 31  |  Issue : 3  |  Page : 201-203

Successful use of botulinum toxin a in intractable, severe muscle spasms in spinal cord injury: A case report

B.J. Government Medical College and Sassoon General Hospitals, Pune, Maharashtra, India

Correspondence Address:
Gautam D Modak
Vishwadhar, Near Mata Mandir, Dharampeth, Nagpur 440010, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpn.ijpn_35_17

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Botulinum toxin is a protein produced by Clostridium botulinum, which inhibits muscle contraction by transiently blocking the release of acetylcholine at the neuromuscular junction. At a neuromuscular junction, the toxin inactivates some of the fusion proteins, such as SNAP-25, syntaxin, or synaptobrevin, which are essential for cellular function. This process involves the temporary inhibition of presynaptic acetylcholine release; consequently, its effects are restricted to motor neurons that depend on the cholinergic transmission (muscular plate, gland innervating cells). Injections of botulinum toxin A have been shown to be useful in the treatment of etiologically diverse types of muscle spasms. Ultrasonography (USG) has been used as a guide for confirming muscle fasciculations and also is an effective tool for confirming precise needle positioning and correct drug placement. We describe a case of a 25-year-old man with meningomyelocele and paraparesis with painful muscle spasms in bilateral thighs treated by USG-guided botulinum toxin injection.

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