Indian Journal of Pain

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 29  |  Issue : 3  |  Page : 150--154

Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals


Chaitali Diwane, Rupali Patil, Prashant Vyavahare, Rajendra Bhambar 
 Department of Pharmacology, MGV's Pharmacy College, Nashik, Maharashtra, India

Correspondence Address:
Chaitali Diwane
MGVSQs Pharmacy College, Nashik - 422 003, Maharashtra
India

Background: Neuropathic pain is a pain initiated or caused by a primary lesion or dysfunction of the nervous system. Material and Methods: In this study, we evaluated the effect of alcoholic extract of roots and rhizomes of Rubia cordifolia on the development and expression of neuropathic pain induced by paclitaxel in sciatic nerve ligated rats. A peripheral mononeuropathy was produced in adult Wistar rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia, and spontaneous pain were produced. Treatment with paclitaxel (2 mg/kg i.p. on 7 th , 10 th , and 21 st day) produced long-lasting (2-3 weeks) heat hyperalgesia and cold allodynia in rats. Conclusion: Co-administration of R. cordifolia extract for 21 days significantly decreased pain indicating its usefulness in neuropathic pain.


How to cite this article:
Diwane C, Patil R, Vyavahare P, Bhambar R. Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals.Indian J Pain 2015;29:150-154


How to cite this URL:
Diwane C, Patil R, Vyavahare P, Bhambar R. Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals. Indian J Pain [serial online] 2015 [cited 2019 Jun 17 ];29:150-154
Available from: http://www.indianjpain.org/article.asp?issn=0970-5333;year=2015;volume=29;issue=3;spage=150;epage=154;aulast=Diwane;type=0