Indian Journal of Pain

CASE REPORT
Year
: 2017  |  Volume : 31  |  Issue : 3  |  Page : 201--203

Successful use of botulinum toxin a in intractable, severe muscle spasms in spinal cord injury: A case report


Madhuri A Lokapur, Gautam D Modak, Kalpana V Kelkar, Vinaya R Kulkarni 
 B.J. Government Medical College and Sassoon General Hospitals, Pune, Maharashtra, India

Correspondence Address:
Gautam D Modak
Vishwadhar, Near Mata Mandir, Dharampeth, Nagpur 440010, Maharashtra
India

Botulinum toxin is a protein produced by Clostridium botulinum, which inhibits muscle contraction by transiently blocking the release of acetylcholine at the neuromuscular junction. At a neuromuscular junction, the toxin inactivates some of the fusion proteins, such as SNAP-25, syntaxin, or synaptobrevin, which are essential for cellular function. This process involves the temporary inhibition of presynaptic acetylcholine release; consequently, its effects are restricted to motor neurons that depend on the cholinergic transmission (muscular plate, gland innervating cells). Injections of botulinum toxin A have been shown to be useful in the treatment of etiologically diverse types of muscle spasms. Ultrasonography (USG) has been used as a guide for confirming muscle fasciculations and also is an effective tool for confirming precise needle positioning and correct drug placement. We describe a case of a 25-year-old man with meningomyelocele and paraparesis with painful muscle spasms in bilateral thighs treated by USG-guided botulinum toxin injection.


How to cite this article:
Lokapur MA, Modak GD, Kelkar KV, Kulkarni VR. Successful use of botulinum toxin a in intractable, severe muscle spasms in spinal cord injury: A case report.Indian J Pain 2017;31:201-203


How to cite this URL:
Lokapur MA, Modak GD, Kelkar KV, Kulkarni VR. Successful use of botulinum toxin a in intractable, severe muscle spasms in spinal cord injury: A case report. Indian J Pain [serial online] 2017 [cited 2019 Sep 17 ];31:201-203
Available from: http://www.indianjpain.org/article.asp?issn=0970-5333;year=2017;volume=31;issue=3;spage=201;epage=203;aulast=Lokapur;type=0