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Year : 2015  |  Volume : 29  |  Issue : 1  |  Page : 52-54

Significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patient

Department of Anesthesia and ICU, Khoula Hospital, Muscat, Sultanate of Oman

Correspondence Address:
Naresh Kaul
Department of Anesthesia and ICU, Khoula Hospital, Muscat, Sultanate of Oman

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-5333.145949

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A 12-year-old ASA I female patient underwent correction of posterior scoliosis of dorsolumbar spine under total intravenous anesthesia using a combination of remifentanil and propofol. Induced hypotension was maintained between 55 and 65 mmHg. Intraoperatively, patient received a single injection of 1.0 g paracetamol. Surgery lasted 6 h and 40 min and was essentially uneventful. A follow-up investigation in the intensive care unit 6 h after the surgery revealed alanine transaminase levels of 547 I/U. This increased to 924 I/U on the 2 nd postoperative day after the patient received 500 mg per-rectal paracetamol. Stopping administration of paracetamol restored alanine transaminase level to normal without needing N-acetylcysteine.

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