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Year : 2016  |  Volume : 30  |  Issue : 3  |  Page : 194-197

Efficacy of low dose intravenous dexamethasone for prolongation of analgesia in supraclavicular block: Randomized controlled trial

1 Department of Anaesthesiology and Critical Care, Indira Gandhi Medical College and Research Institute, Puducherry, India
2 Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
3 Department of Community Medicine, Indira Gandhi Medical College and Research Institute, Puducherry, India
4 Department of Orthopaedics, Indira Gandhi Medical College and Research Institute, Puducherry, India

Correspondence Address:
Stalin Vinayagam
FR4, Sri Anbalaya Apartments, 17th Cross Street, Krishna Nagar, Puducherry - 605 008
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-5333.198059

Clinical trial registration REF/2015/08/009652 , URL - http://ctri.nic.in

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Background: Dexamethasone, a long-acting glucocorticoid is used as an additive along with local anesthetics perineurally to prolong the duration of neuraxial blocks. The aim of this prospective, randomized, double-blind study was to evaluate the efficacy of low-dose intravenous (IV) dexamethasone (2 mg) along with bupivacaine for prolongation of supraclavicular block in patients undergoing upper limb surgeries. Materials and Methods: Sixty American Society of Anaesthesiologists 1 and 2 patients, aged between 18 and 60 years were included in this study and randomized into two groups: Group D (dexamethasone group) and Group C (control group). Ultrasound-guided supraclavicular block was performed and patients belonging to Group D received 25 ml of 0.5% bupivacaine and 2 mg (1 ml) dexamethasone intravenously while patients belonging to Group C received 25 ml of 0.5% bupivacaine and 1 ml of normal saline intravenously. Duration of analgesia, motor blockade, and requirement of rescue analgesic were recorded. Results were analyzed using unpaired Student's t-test and Chi-squared test. P <0.05 was considered statistically significant. Results: Duration of analgesia in Group D was 11.88 ± 1.31 h as compared to 6.47 ± 0.93 in Group C (P < 0.05). Rescue analgesic requirement was significantly less in Group D (38.00 ± 20.51) as compared to Group C (173.33 ± 34.07). Patient satisfaction and quality of sleep was better in patients belonging to Group D. Conclusion: We conclude that low dose IV dexamethasone significantly prolongs the duration of analgesia and reduces analgesic requirements without producing any significant side effects.

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