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Year : 2018  |  Volume : 32  |  Issue : 2  |  Page : 96-101

Comparative efficacy and safety of intravenous tramadol and nalbuphine for pain relief in postoperative patients

1 Department of Anesthesia, Yashoda Hospitals, Secunderabad, Telangana, India
2 Department of Anaesthesia, D.Y. Patil University School of Medicine, Navi Mumbai, Maharashtra, India

Correspondence Address:
Dr. Varsha Vyas
Department of Anaesthesia, D.Y. Patil University School of Medicine, Navi Mumbai, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpn.ijpn_40_18

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Aim: To compare the efficacy and safety of single-dose intravenous nalbuphine versus intravenous tramadol for postoperative analgesia. Materials and Methods: In this prospective randomized study, adults with the American Society of Anesthesiologists physical status class I and II undergoing elective surgeries performed under general anesthesia, resulting in mild-to-moderate pain (n = 60), received either intravenous nalbuphine (10 mg) or tramadol (100 mg). Visual analog scale scores for pain, sedation, and nausea and vomiting were monitored for 4 h and compared between the two groups. Statistical Analysis: The mean scores within the groups were analyzed by paired t-test, whereas between the groups by unpaired t-test. The median scores were analyzed by using Mann–Whitney U test. P value <0.05 was considered statistically significant. Results: Reduction in pain after drug administration was statistically significant at all-time points as compared to before administration in both groups (P < 0.5). Pain reduction after 5 min (P = 0.01) and 30 min (P = 0.03) was significantly better with tramadol, whereas after 4 h, it was better with nalbuphine (P < 0.05). Incidence of nausea and vomiting in tramadol and nalbuphine groups was 23.3% and 40%, respectively. No statistically significant difference was observed in sedation, nausea, and vomiting scores between two groups at any time point (P > 0.05). Conclusion: Intravenous nalbuphine and tramadol both provided effective pain relief in patients with postoperative pain. Tramadol resulted in early pain relief but higher incidence of nausea and vomiting.

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