| REVIEW ARTICLE |
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| Year : 2020 | Volume
: 34
| Issue : 1 | Page : 3-7 |
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Central sensitization and its role in chronic pain: What can ketamine do?
Vinita Singh, Jack Williams Shteamer, Jonathan Seth Lowe, Mayson Callaway Augustus
Department of Anesthesia, Emory University, Atlanta, GA, USA
Correspondence Address:
Dr. Vinita Singh
1364 Clifton Rd, Emory University Hospital, Atlanta, 30322, GA
USA
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijpn.ijpn_25_20
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Central sensitization plays a crucial role in the development of chronic pain. NMDA receptors play a key role in central sensitization. Ketamine, an NMDA receptor antagonist, can help in refractory chronic pain. Although intravenous is the most common route utilized for delivery of ketamine, other routes such as oral, subcutaneous, topical and intranasal, have been explored. Here we review key research articles regarding the use of ketamine for chronic pain.
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