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Year : 2021  |  Volume : 35  |  Issue : 1  |  Page : 4-10

Bone cancer pain

1 Department of Pain Clinic, National Institute of Cancer, México City, USA
2 Laboratorio de Farmacología, Unidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamaulipas, Reynosa, TAMPS, México, USA
3 Department of Pain Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

Correspondence Address:
Prof. Dhanalakshmi Koyyalagunta
Department of Pain Medicine, The University of Texas M.D. Anderson Cancer Center, 1400 Holcombe Blvd., Unit 409, Houston 77030, TX
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpn.ijpn_4_21

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In 2012, the International Agency for Research on Cancer reported 14.1 million new cancer cases, 8.2 million cancer deaths, and 32.6 million people living with cancer. Cancer pain not only causes significant suffering but also contributes to a decreased quality of life, functional status, and greatly increases health-care costs. The bones are a common site for metastases, especially tumors involving breast, lung, prostate, and kidneys. This can lead to significant pain, pathological fractures, compression of the spinal cord, poor quality of life, and increased mortality. Pathophysiology of cancer-induced bone pain is complex and has neuropathic and nociceptive characteristics. The aim of the treatment of bone metastases is palliating painful symptoms and preventing progression of skeletal-related events. A multimodal approach including various cancer therapies, analgesic and adjuvant agents, and interventional modalities should be used. This review focuses on the pathophysiology of bone cancer pain and pharmacological and non-pharmacological modalities that reduce bone cancer pain.

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